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Vadim Zinchuk, M.D., Ph.D. |  | |||
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Room: 416
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Visit Blog | ||
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Scientific interests: | ||
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• Molecular mechansims involved in the regulation of traffic and sorting of multidrug resistance (MDR) proteins. | ||
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• Role of membrane-associated, ATP-dependent transporters in the process of nucleotide signalling in the nervous system. | ||
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• Advanced imaging techniques, focusing on quantitative colocalization analysis, fluorescence energy transfer (FRET), and imaging of living cells. | ||
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Selected publications: | ||
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Zinchuk V, Zinchuk O, Okada T. (2007) Quantitative colocalization analysis of multicolor confocal immunofluorescence microscopy images: pushing pixels to explore biological phenomena. Acta Histochem Cytochem 40:101-111. (Review). Zinchuk V, Zinchuk O, Akimaru K, Moriya F, Okada T. (2007) Ethanol consumption alters expression and colocalization of bile salt export pump and multidrug resistance protein 2 in the rat. Histochem Cell Biol, 127:503-512. Zinchuk O, Zinchuk V. (2006) Dynamics of cellular responses studied by quantitative colocalization analysis. Microscopy and Analysis 20:S13-S15. (Review). Zinchuk V, Zinchuk O, Okada T. (2005) Experimental LPS-induced cholestasis alters subcellular distribution and affects colocalization of Mrp2 and Bsep proteins: a quantitative colocalization study. Microsc Res Tech 67:65-70. Zinchuk O, Fukushima A, Zinchuk V, Fukata K, Ueno H. (2005) Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF-receptors in conjunctivitis. Mol Vis 11:114-123. Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, Vance D, Anantanarayanan M, Chait BT, Breslow JL. (2003) Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipids and cholesterol. J Lipid Res 44:1605-1613. Zinchuk VS, Okada T, Seguchi H. (2002) Combined biochemistry and histocytochemistry as a tool to investigate ecto-ATPase activity in the cardiac muscle. Microsc Res Tech 58:427-431. Okada T, Zinchuk VS, Seguchi H. (2002) Lipopolysaccharide administration increases acid and alkaline phosphatase reactivity in the rat cardiac muscle. Microsc Res Tech 58:421-426. Zinchuk VS. (2002) Histology and histochemistry of heart muscle: toward function with structure in mind. Microsc Res Tech 58:377. Zinchuk VS, Okada T, Akimaru K, Seguchi H. (2002) Asynchronous expression and colocalization of Bsep and Mrp2 during development of rat liver. Am J Physiol Gastrointest Liver Physiol 282:G540-G548. Zinchuk VS, Okada T, Seguchi H. (2001) Lipopolysaccharide alters ecto-ATP-diphosphohydrolase and causes relocation of its reaction product in experimental intrahepatic cholestasis. Cell Tissue Res 304:103-109. Okada T, Zinchuk VS, Kobayashi T, Seguchi H. (1999) Dynamics of rat liver ecto-ATPase during development suggests its involvement in bile acid efflux. A cytochemical view. Cell Tissue Res 298:511-518. Zinchuk VS, Okada T, Kobayashi T. (1999) Ecto-ATPase activity in the rat cardiac muscle: biochemical characteristics and histocytochemical localization. Cell Tissue Res 298:499-509. Zinchuk VS, Okada T, Kobayashi T. (1999) Detection of ecto-ATPase activity in synaptic plasma membranes for studying extracellular ATP-induced signal transduction. Brain Res Brain Res Protocol 4:258-265. Fukumoto M, Ushida T, Zinchuk VS, Yamamoto H, Yoshida S. (1999) Contralateral thalamic perfusion in patients with reflex sympathetic dystrophy syndrome. Lancet 354:1790-1791. Zinchuk VS, Okada T, Kobayashi T, Seguchi H. (1999) Ecto-ATPase activity in cerebellum: implication to function of synaptic transmission. Brain Res 815:111-115. Zinchuk VS, Kobayashi T, Garcia del Saz E, Seguchi H. (1997) Biochemical properties and cytochemical localization of ouabain-insensitive, potassium-dependent, p-nitrophenylphosphatase activity in rat atrial myocytes. J Histochem Cytochem 45:177-187. | ||
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University page > Index > People > Zinchuk | ||
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Copyright © 2005-2006 Department of Anatomy & Cell Biology, Kochi University Faculty of Medicine. All rights reserved. | ||
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