1) Shibukawa, Y., Takahashi, M., Laffont, I., Honke, K., and Taniguchi, N.:
Downregulation of hydrogen peroxide-induced PKCd activation in N-acetylglucosaminyltransferase
III transfected HeLaS3 cells.
J Biol. Chem. 2003;278:3197-3203
2) Korekane, H., Taguchi, T., Sakamoto, Y., Honke, K., Dohmae, N., Salminen, H.,
Toivonen, S., Helin, J., Takio, K., Renkonnen, O., and Taniguchi, N.:
Purification and cDNA cloning of UDP-GlcNAc:GlcNAc･1-3Gal･1-4Glc(NAc)-R [GlcNAc to Gal]･
1,6N-acetylglucosaminyltransferase from rat small intestine: A major carrier of dIGnT activity
in rat small intestine.
Glycobiology 2003;13:387-400
3) Park, Y. S., Koh, Y. H., Takahashi, M., Miyamoto, Y., Suzuki, K., Dohmae, N., Takio, K.,
Honke, K., Taniguchi, N.: Identification of the binding site of methylglyoxal on
glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding
to glutathione binding sites Arg 184 and 185.
Free Radic. Res. 2003;37: 205-211.
4) Kimoto, K., Suzuki, K., Kizaki, T., Hitomi, Y., Ishida, H., Katsuta, H., Itoh, E., Ookawara,
T., Suzuki, K., Honke, K., Ohno, H.: Gliclazide protects pancreatic beta-cells from damage
by hydrogen peroxide.
Biochem. Biophys. Res. Commun. 2003;303:112-119
5) Sasai, K., Ikeda, Y., Ihara, H., Honke, K., and Taniguchi, N.: Caveolin-1 regulates
the functional localization of N-acetylglucosaminyltransferase-III within the Golgi apparatus.
J. Biol Chem. 2003;278: 25295-25301
6) Inamori, K., Endo, T., Ide, Y., Fujii, S., Gu, J., Honke, K., and Taniguchi, N.:
Molecular cloning and characterization of human GnT-IX, a novel β1,6-N-acetylglucosaminyltransferase
that is specifically expressed in the brain.
J. Biol. Chem. 2003;278:43102-43109
7) Noda, K., Miyoshi, E., Gu, J., Gao, C. X., Nakahara, S., Kitada, T., Honke, K., Suzuki, K.,
Yoshihara, H., Yoshikawa, K., Kawano, K., Tonetti, M., Kasahara, A., Hori, M., Hayashi, N., and
Taniguchi, N.: Relationship between elevated FX expression and increased production of GDP-L-fucose,
a common donor substrate for fucosylation in human hepatocellular carcinoma and hepatoma cell lines.
Cancer Res. 2003;63:6282-6289
8) Ihara, S., Miyoshi, E., Nakahara, S., Sakiyama, H., Ihara, H., Akinaga, A., Honke, K., Dickson,
R. B., Lin, C. Y., Taniguchi, N.: Addition of β1-6 GlcNAc branching to the oligosaccharide attached
to Asn 772 in the serine protease domain of matriptase plays a pivotal role in its stability and
resistance against trypsin.
Glycobiology 2004;14:139-146
9) Gu, J., Zhao, Y., Isaji, T., Shibukawa, Y., Ihara, H., Takahashi, M., Ikeda, Y., Miyoshi, E., Honke, K.,
and Taniguchi, N.: β1,4-N-Acetylglucosaminyltransferase III down-regulates neurite outgrowth induced by
costimulation of epidermal growth factor and integrins through the Ras/ERK signaling pathway in PC12 cells.
Glycobiology 2004;14:177-186
10) Ogawa, D., Shikata, K., Honke, K., Sato, S., Matsuda, M., Nagase, R., Tone, A., Okada, S., Usui, H.,
Wada, J., Miyasaka, M., Kawashima, H., Suzuki, Y., Suzuki, T., Taniguchi, N., Hirahara, Y., Tadano-Aritomi,
K., Ishizuka, I., Tedder, T. F., and Makino, H.: Cerebroside sulfotransferase deficiency ameliorates
L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction.
J. Biol. Chem.
2004;279:2085-2090
11) Inamori, K., Endo, T., Gu, J., Matsuo, I., Ito, Y., Fujii, S., Iwasaki, H., Narimatsu, H., Miyoshi, E.,
Honke, K., and Taniguchi, N.: N-Acetylglucosaminyltransferase IX acts on the GlcNAcβ1,2-Manα1-Ser/Thr moiety,
forming a 2,6-branched structure in brain O-mannosyl glycan.
J. Biol. Chem. 2004;279:2337-2340
12) Nakahara, S., Miyoshi, E., Noda, K., Ihara, S., Gu, J., Honke, K., Inohara, H., Kubo, T., and Taniguchi,
N.: Involvement of oligosaccharide changes in alpha5beta1 integrin in a cisplatin-resistant human squamous
cell carcinoma cell line.
Mol Cancer Ther. 2003;2:1207-1214
13) Hirahara, Y., Bansal, R., Honke, K., Ikenaka, K., and Wada, Y.: Sulfatide is a negative regulator of
oligodendrocyte differentiation: development in sulfatide-null mice.
Glia 2004;45:269-277
14) Isaji, T., Gu, J., Nishiuchi, R., Zhao, Y., Takahashi, M., Miyoshi, E., Honke, K., Sekiguchi, K., and
Taniguchi, N.: Introduction of bisecting GlcNAc into integrin α5β1 reduces ligand binding and down-regulates
cell adhesion and cell migration.
J. Biol. Chem. 2004;279:19747-19754
15) Miyahara, K., Kuge, H., Shizuta, Y., and Honke, K.: Three repeats of CCCCTCC on the pyrimidine-rich
sequence in the proximal 5' flanking region are required for efficient transcriptional activity of the
human endothelial nitric oxide synthase gene.
Free Radic. Res. 2004;38:87-95
16) Wu, Z., Honke, K., Zhang, L., Zha, L., and Taniguchi, N.: Lactosylsulfatide expression in hepatocellular
carcinoma cells enhances cell adhesion to vitronectin and intrahepatic metastasis in nude mice.
Int. J. Cancer 2004;110:504-510
17) Zhang, Y., Hayashi, Y., Cheng, X., Watanabe, T., Wang, X., Taniguchi, N., and Honke, K.:
Testis-specific sulfoglycolipid, seminolipid, is essential for germ cell function in spermatogenesis.
Glycobiology 2005;15:649-654
18) Cheng, X., Zhang, Y., Kotani, N., Watanabe, T., Lee, S., Wang, X., Kawashima, I., Tai, T.,
Taniguchi, N., and Honke, K.: Production of a recombinant single-chain variable-fragment (scFv)
antibody against sulfoglycolipid.
J. Biochem. 2005;137:415-421
19) Gao, C., Miyoshi, E., Uozumi, N., Takamiya, R., Wang, X., Noda, K., Gu, J., Honke, K., Wada, Y.,
and Taniguchi, N.: Bisecting GlcNAc mediates the binding of annexin V to Hsp47.
Glycobiology 2005;15:1067-1075
20) Eguchi, H., Ikeda, Y., Ookawara, T., Koyota, S., Fujiwara, N., Honke, K., Wang, P., Taniguchi, N.,
and Suzuki, K.: Modification of oligosaccharides by reactive oxygen species decreases sialyl lewis
x-mediated cell adhesion.
Glycobiology 2005;15:1094-1101
21) Kuribayashi, I., Nomoto, S., Massa, G., Oostdijk, W., Wit, J. M., Wolffenbuttel, B. H., Shizuta, Y.,
and Honke, K.: Steroid 11-β-hydroxylase deficiency caused by compound heterozygosity for a novel mutation,
p.G314R, in one CYP11B1 allele, and a chimeric CYP11B2/CYP11B1 in the other allele.
Horm. Res. 2005;63:284-293
22) Wang, X., Inoue, S., Gu, J., Miyoshi, E., Noda, K., Li, W., Mizuno-Horikawa, Y., Nakano, M., Asahi, M.,
Takahashi, M., Uozumi, N., Ihara, S., Lee, S. H., Ikeda, Y., Yamaguchi, Y., Aze, Y., Tomiyama, Y., Fujii, J.,
Suzuki, K., Kondo, A., Shapiro, S. D., Lopez-Otin, C., Kuwaki, T., Okabe, M., Honke, K., and Taniguchi, N.:
Dysregulation of TGF-β1 receptor activation leads to abnormal lung development and emphysema-like phenotype
in core fucose-deficient mice.
Proc. Natl. Acad. Sci. U. S. A. 2005;102:15791-15796
23) Marcus, J., Honigbaum, S., Shroff, S., Honke, K., Rosenbluth, J., Dupree, J. L.: Sulfatide is
essential for the maintenance of CNS myelin and axon structure.
Glia 2006;53:372-381
24) Wang, X., Gu, J., Ihara, H., Miyoshi, E., Honke, K., and Taniguchi, N.: Core fucosylation regulates
epidermal growth factor receptor-mediated intracellular signaling.
J. Biol. Chem. 2006;281:2572-2577
25) Watanabe, T., Ihara, H., Miyoshi, E., Honke, K., Taniguchi, N., and Taguchi, T.: A specific detection
of GlcNAcβ1-6Manα1 branches in N-linked glycoproteins based on the specificity of
N-acetylglucosaminyltransferase VI.
Glycobiology 2006;16:431-439
26) Yamamoto, K., Higashi, S., Kioi, M., Tsunezumi, J., Honke, K., Miyazaki, K.: Binding of active
matrilysin to cell surface cholesterol sulfate is essential for its membrane-associated proteolytic
action and induction of homotypic cell adhesion.
J. Biol. Chem. 2006;281:9170-9180
27) Greimel, P., Jabs, S., Storch, S., Cherif, S., Honke, K., Braulke, T., and Thiem, J.: In vitro
sulfation of N-acetyllactosaminide by soluble recombinant human β-Gal-3'-sulfotransferase.
Carbohydr. Res. 2006;341:918-924
28) Lee, S., Takahashi, M., Honke, K., Miyoshi, E., Osumi, D., Sakiyama, H., Ekuni, A., Wang, X.,
Inoue, S., Gu, J., Kadomatsu, K., and Taniguchi, N.: Loss of core fucosylation of low-density
lipoprotein receptor-related protein-1 impairs its function, leading to the upregulation of serum
levels of insulin-like growth factor-binding protein 3 in Fut8-/- mice.
J. Biochem. 2006;139:391-398
29) Li, W., Nakagawa, T., Koyama, N., Wang, X., Jin, J., Mizuno-Horikawa, Y., Gu, J., Miyoshi, E.,
Kato, I., Honke, K., Taniguchi, N., and Kondo, A.: Down-regulation of trypsinogen expression is
associated with growth retardation in α1,6-fucosyltransferase-deficient mice: attenuation of
proteinase-activated receptor 2 activity.
Glycobiology 2006;16:1007-1019
30) Ihara, H., Ikeda, Y., Toma, S., Wang, X., Suzuki, T., Gu, J., Miyoshi, E., Tsukihara, T.,
Honke, K., Matsumoto, A., Nakagawa, A., and Taniguchi, N.: Crystal structure of mammalian
α1,6-fucosyltransferase, FUT8.
Glycobiology 2007;17:455-466
31) Li, W., Takahashi, M., Shibukawa, Y., Yokoe, S., Gu, J., Miyoshi, E., Honke, K., Ikeda, Y.,
and Taniguchi, N.: Introduction of bisecting GlcNAc in N-glycans of adenylyl cyclase III enhances
its activity.
Glycobiology 2007;17:655-662
32) Rashel, M., Uchiyama, J., Ujihara, T., Uehara, Y., Kuramoto, S., Sugihara, S., Yagyu, K.,
Muraoka, A., Sugai, M., Hiramatsu, K., Honke, K., and Matsuzaki, S.: Efficient elimination of
multidrug-resitant Staphylococcus aureus by cloned lysine derived from bacteriophage φMR11.
J. Infect. Dis. 2007;196:1237-1247
33) Guchhait, P., Shrimpton1, C.N., Honke, K., Rumbaut, R. E., Lopez, J.A., and Thiagarajan, P.:
Effect of an anti-sulfatide ScFv on platelet function.
Thrombosis and Haemostasis 2008;9:552-557
34) Takahashi, T., Murakami, K., Nagakura, M., Kishita, H., Watanabe, S., Honke, K., Ogura, K.,
Tai, T., Kawasaki, K., Miyamoto, D., Hidari, K.I., Guo, C, Suzuki, Y., and Suzuki, T.:
Sulfatide is required for efficient replication of influenza A virus.
J. Virol. 2008;82:5940-5950
35) Rashel, M., Uchiyama, J., Takemura, I., Hoshiba, H., Ujihara, T., Takatsuji, H., Honke, K.,
and Matsuzaki, S.: Tail-associated structural protein gp61 of Staphylococcus aureus phage φMR11
has bifunctional lytic activity.
FEMS Microbiol. Lett. 2008;284:9-16
36) Kotani, N., Gu, J., Isaji, T., Udaka, K., Taniguchi, N., and Honke, K.: Biochemical visualization
of cell surface molecular clustering in living cells.
Proc. Natl. Acad. Sci. U. S. A. 2008;105:7405-7409
37) Kondo, Y., Tokuda, N., Fan, X., Yamashita, T., Honke, K., Takematsu, H., Togayachi, A., Ohta, M.,
Kotzusumi, Y., Narimatsu, H., Tajima, O., Furukawa, K., and Furukawa, K.: Glycosphingolipids are not
pivotal receptors for Subtilase cytotoxin in vivo: Sensitivity analysis with glycosylation-defective
mutant mice.
Biochem. Biophys. Res. Commun. 2008 Nov 6. [Epub ahead of print]
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1) Honke, K., Ikeda N, Taniguch N: Differences in recognition of sulfated and sialylated carbohydrate
chains.
Methods in Enzymol. 2003;363:222-229
2) Gao, C. X., Honke, K., and Taniguchi, N.: Carbohydrate binding activity of annexin V toward a
bisecting N-acetylglucosamine.
Methods Enzymol. 2003;363:34-47
3) Miyamoto, Y., Koh, Y. H., Park, Y. S., Fujiwara, N., Sakiyama, H., Misonou, Y., Ookawara, T.,
Suzuki, K., Honke, K., and Taniguchi, N.: Oxidative stress caused by inactivation of glutathione
peroxidase and adaptive responses.
Biol. Chem. 2003;384:567-574
4) Takahashi, M., Tsuda, T., Ikeda, Y., Honke, K., and Taniguchi, N.: Role of N-glycans in
growth factor signaling.
Glycoconj. J. 2003;20:207-12
5) Honke, K., Zhang, Y., Cheng, X., Kotani, N., and Taniguchi, N.: Biological roles of
sulfoglycolipids and pathophysiology of their deficiency.
Glycoconj. J. 2004;21:59-62
6) Taniguchi, N., Miyoshi, E., Gu, J., Honke, K., and Matsumoto, A.: Decoding sugar functions by
identifying target glycoproteins.
Curr. Opin. Struct. Biol. 2006;16:561-566
7) Wang, X., Gu, J., Miyoshi, E., Honke, K., and Taniguchi, N.: Phenotype changes of Fut8
knockout mouse: core fucosylation is crucial for the function of growth factor receptor(s).
Methods Enzymol. 2006;417:11-22
その他の業績
PubMedへリンク
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●Katsumi Toda,
エストロゲン合成酵素遺伝子欠損マウスを用いた研究論文 |
1) K. Toda, S.Okada, K. Nakamura, M. Nishihara, K. Yokotani, and Y. Shizuta:
Concentrations of monoamines and acetylcoline in the brains of mice lacking the aromatase
cytochrome P450 gene. In "Molecular Steroidogenesis" (eds. M. Okamoto, Y. Ishimura, and H. Newada) pp. 141-143, (2000) Frontiers
Science Series No. 29, Universal Academy Press, Inc, Tokyo, Japan. (International Symposium
on Molecular Steroidogenesis, Proceedings of the 52nd Yamada Conference at Nara)
2) Y. Nemoto, K. Toda, M. Ono, K. F-Adachi, T. Saibara, S. Onishi, H. Enzan, T. Okada and Y. Shizuta: Altered
expression of fatty acid-metabolizing enzymes in aromatase-deficient mice.
J. Clin. Invest. (2000) 105,1819-1825.
3) K. Toda, T. Okada, T. Saibara, S. Onishi and Y. Shizuta: A loss of aggressive behaviour and its reinstatement by
estrogen in mice lacking the aromatase gene (Cyp 19).
J. Endocrinol. (2001) 168, 217-220
4) K. Toda, T. Okada, K. Takeda, S. Akira, T. Saibara, M. Shiraishi, S. Onishi and Y. Shizuta: Oestrogen at neonatal stage is critical for
reproductive ability of male mice as revealed by supplementation with 17β-oestradiol to aromatase (CYP19) gene knockout mice.
J. Endocrinol. (2001) 168, 455-463.
5) K. Toda, K. Takeda, T. Okada, S. Akira, T. Saibara, T. Kaname, K. Yamamura, S. Onishi and Y. Shizuta:
Targeted disruption of the aromatase P450 gene (Cyp19) in mice and their ovarian and uterine responses to 17β-oestradiol.
J. Endocrinol. (2001) 170, 99-111.
6) K. Toda, K. Takeda, S. Akira, T. Saibara, T. Okada, S. Onishi and Y. Shizuta: Alterations in hepatic expression of fatty-acid
metabolising enzymes in ArKO mice and their reversal by the treatment with 17β-estradiol or a peroxisome proliferator.
J. Steroid. Biochem. Mol. Biol. (2001) 79,11-17
7) C. Miyaura, K. Toda, M. Inada, T. Ohshiba, C. Matsumoto, T. Okada, M. Ito, Y. Shizuta and A. Ito: Sex- and age-related response
to aromatase-deficiency in bone.
Biochem. Biophys. Res. Commun. (2001) 280,1062-1068.
8) T. Yoshikawa, K.Toda, Y. Nemoto, M. Ono, S. Iwasaki, T. Maeda, T. Saibara, Y. Hayashi, E. Miyazaki, M. Hiroi, H. Enzan, Y. Shizuta
and S. Onishi: Aromatase-defiecient (ArKO) mice are retrieved from severe hepatic steatosis by peroxisome proliferator administration.
Hepatol. Res. (2002) 22, 278-287
9) K. Toda, C. Miyaura, T. Okada and Y. Shizuta: Dietary bisphenol A prevents ovarian degeneration and bone loss in
female mice lacking the aromatase gene (Cyp19).
Eur. J. Biochem. (2002) 269, 2214-2222
10) C.-L. Li , K. Toda, T. Saibara, T. Zhang, M. Ono, S. Iwasaki, T. Maeda, T. Okada, Y. Hayashi, H. Enzan, Y. Shizuta and S. Onishi:
Estrogen deficiency results in enhanced expression of Smoothened of the Hedgehog signaling in the thymus and affects thymocyte development.
Int. Immunopharmacol. (2002) 2, 823-833.
11) K.Takeda , K.Toda, T.Saibara, M. Nakagawa, K. Saika, S. Onishi,T. Sugiura and Y. Shizuta:
Progressive development of insulin resistant phenotype in male mice with complete aromatase(CYP19) deficiency.
J. Endocrinol
(2003) 176, 237-246.
12) K. Toda, T. Okada, C. Miyaura,and T. Saibara: Fenofibrate,a ligand
for PPAR?, inhibits aromatase cytochrome P450 expression in the ovary of mouse.
J. Lipid Res. (2003) 44, 265-270.
13) T. Egawa, K.Toda, Y. Nemoto, M. Ono, N. Akisaw, T. Saibara, Y. Hayashi, M. Hiroi, H. Enzan, S. Onishi:
Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.
Lipids(2003) 38, 519-523.
14) K. Yamada, Y. Kondo, K. Toda, Y. Sakuma: Behavioral ewvaluation of sociosexual dysfunction in aromatase knockout mice.
Jpn. J. Reprod. Endocrinol. (2003) 8, 61-66
15) K. Toda, Y. Okada, M. Zubair, K.I.Morohashi,T. Saibara, T. Okada: Aromatase-Knockout Mouse
Carrying an Estrogen-Inducible Enhanced Green Fluorescent Protein Gene
Facilitates Detection of Estrogen Actions in Vivo.
Endocrinology 2004 in press
その他の業績
PubMedへリンク
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Copyright(C)2006-2010 Department of Biochemistry, Kochi Medical School. All rights reserved.
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