高知大学医学部病理学講座
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高知大学医学部
医学科病理学講座

高知県南国市岡豊町小蓮
基礎・臨床研究棟3F西
Tel: 088-880-2330
Fax: 088-880-2332
〈メールアドレス〉

高知大学

研究業績

2015年
Hayashi Y, Osanai M, Lee GH  
 
NOTCH2 signaling confers immature morphology and aggressiveness in human  
 hepatocellular carcinoma cells.  Oncol Rep. 34(4):1650-8.
Kurabayashi A
, Inoue K, Fukuhara H, Karashima T, Fukata S, Kawada C, Shuin T, Furihata M
.
 Combination with third-generation bisphosphonate (YM529) and interferon-alpha can
 inhibit the progression of established bone renal cell carcinoma.
 Cancer Sci. 106(8):1092-1099

2014年

Wei S, Fukuhara H, Chen G, Kawada C, Kurabayashi A, Furihata M, Inoue K, Shuin T
 Terrestrosin D, a Steroidal Saponin from Tribulus terrestris L., Inhibits Growth and 
 Angiogenesis of Human Prostate Cancer in vitro and in vivo. Pathobiology.81(3):123- 132
Taniuchi K, Furihata M, Iwasaki S, Tanaka K, Shimizu T, Saito M, Saibara T
 RUVBL1 directly binds actin filaments and induces formation of cell protrusions to
 promote pancreatic cancer cell invasion. Int J Oncol. 44(6):1945-1954
Kakinuma Y, Noguchi T, Okazaki K, Oikawa S, Iketani M, Kurabayashi M, Furihata M, Sato T
 Antimuscle atrophy effect of nicotine targets muscle satellite cells partly through an
 α7 nicotinic receptor in a murine hindlimb ischemia model. Transl Res. 164(1):32-45
Taniuchi K, Furihata M, Hanazaki K, Saito M, Saibara T
 IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and
 metastasis of pancreatic cancer. Oncotarget. 5(16):6832-6845
Taniuchi K, Furihata M, Saibara T:
 KIF20A-mediated RNA granule transport system promotes the invasiveness of
 pancreatic cancer cells. Neoplasia. 16(12):1082-93
Iguchi M, Osanai M, Hayashi Y, Koentgen F, Lee GH.
 The error-prone DNA polymerase ι provides quantitative resistance to lung
 tumorigenesis and mutagenesis in mice. Oncogene.33 (27): 3612-7

2013年
Nishioka C, Ikezoe T, Furihata M, Yang J, Serada S, Naka T, Nobumoto A, Kataoka S, Tsuda M, Udaka K, Yokoyama A :
 CD34(+) /CD38(-) acute myelogenous leukemia cells aberrantly express CD82 which 
 regulates adhesion and survival of leukemia stem cells. Int J Cancer. 132(9):2006- 2019
Inoue K, Fukuhara H, Kurabayashi A, Furihata M, Tsuda M, Nagakawa K, Fujita H, Utsumi K, Shuin T
 Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by
 ferrochelatase inhibitor in urothelial carcinoma.Cancer Sci. 104(6):765-772
Ueda K, Tatsuguchi A, Saichi N, Toyama A, Tamura K, Furihata M, Takata R, Akamatsu S, Igarashi M, Nakayama M, Sato TA, Ogawa O, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
 Plasma low-molecular-weight proteome profiling identified neuropeptide-y as a prostate
 cancer biomarker polypeptide. J Proteome Res. 12(10):4497-4506
Inoue K, Ashida S, Fukuhara H, Iiyama T, Miyamura M, Kurabayashi M, Furihata M,
 Application of 5-aminolevulinic acid-mediated photodynamic diagnosis to robot-assisted
 laparoscopic radical prostatectomy. Urology. 82(5):1175-1178
Fukuhara H, Inoue K, Kurabayashi M, Furihata M, Fujita H, Utsumi K, Sasaki J, Shuin T
 The inhibition of ferrochelatase enhances 5-aminolevulinic acid-based photodynamic
 action for prostate cancer. Photodiagnosis Photodyn Ther. 10(4):399-409
Kurabayashi A, Kakinuma Y, Morita T, Inoue K, Sato T, Furihata M.

 Conditional VHL gene deletion causes hypoglycemic death associated with
 disproportionately  increased glucose uptake by hepatocytes through an
 upregulated IGF-I receptor. PLoS One. (2013)

2012年
Sakai H, Furihata M, Matsuda C, Takahashi M, Miyazaki H, Konakahara T, Imamura T, Okada T
 Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the
 metastatic potential of mouse breast cancer cells. Clin Exp Metastas. 29(4):327-338
Ha Nguyen H, Takata R, Akamatsu S, Shigemizu D, Tsunoda T, Furihata M, Takahashi A, Kubo M, Kamatani N, Ogawa O, Fujioka T, Nakamura Y, Nakagawa H
 IRX4 at 5p15 suppresses prostate cancer growth through the interaction with vitamin
 D receptor, conferring prostate cancer susceptibility. Hum Mol Genet. 21(9):2076-
 2085
Akamatsu S, Takata R, Haiman CA, Takahashi A, Inoue T, Kubo M, Furihata M, Kamatani N, Inazawa J, Chen GK, Le Marchand L, Kolonel LN, Katoh T, Yamano Y, Yamakado M, Takahashi H, Yamada H, Egawa S, Fujioka T, Henderson BE, Habuchi T, Ogawa O, Nakamura Y, Nakagawa H
 Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer
 susceptibility in Japanese. Nat Genet. 44(4):426-429
Ikezoe T, Yang J, Nishioka C, Honda G, Furihata M, Yokoyama A
 Thrombomodulin protects endothelial cells from a calcineurin inhibitor-induced
 cytotoxicity by upregulation of extracellular signal-regulated kinase/myeloid leukemia
 cell-1 signaling. Arterioscl Throm Vas. 32:2259-2270

2011年
Morita T, Kakinuma Y, Kurabayashi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H
 Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner
 reinforcing resistance to endothelium-targeted glomerulonephropathy. Nephrol Dial
 Transplant. 26:4023-4031
Takeuchi T, Adachi Y, Nagayama T, Furihata M.
 Matrix metalloproteinase-11 overexpressed in lobular carcinoma cells of the breast
 promotes anoikisresistance. Virchows Arch. 459(3):291-7
Takeuchi T, Adachi Y, Nagayama T, Furihata M.
 Nedd4L modulates the transcription of metalloproteinase-1 and -13 genes to increase
 the invasiveactivity of gallbladder cancer. Int J Exp Pathol. 92(2):79-86
Takeuchi T, Tsuzuki H, Numoto S, Furihata M.
 Coexistence of pregnancy-like and cystic hypersecretory hyperplasia with invasive
 lobular carcinoma. Onkologie.34(8-9):448-50
Hayashi Y, Osanai M, Lee GH.
 Fascin-1 expression correlates with repression of E-cadherin expression
 in hepatocellular carcinoma cells and augments their invasiveness in combination with
 matrix metalloproteinases. Cancer Sci. 102(6):1228-35

2010年
Satake H, Tamura K, Furihata M, Anchi T, Sakoda H, Kawada C, Iiyama T, Ashida S, Shuin T
 The ubiquitin-like molecule interferon-stimulated gene 15 is overexpressed in human
 prostate cancer. Oncol Rep. 23(1):11-16
Uemura M, Honma S, Chung S, Takata R, Furihata M, Nishimura K, Nonomura N, Nasu Y, Miki T, Shuin T, Fujioka T, Okuyama A, Nakamura Y, Nakagawa H
 5alphaDH-DOC (5alpha-dihydro-deoxycorticosterone) activates androgen receptor in
 castration-resistant prostate cancer. Cancer Sci. 101(8):1897-1904
Yang J, Ikezoe T, Nishioka C, Furihata M, Yokoyama A
 AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell
 leukemia cells. Mol Cancer Ther. 9(12):3386-3395
Takeuchi T, Tanimura M, Shimamoto T, Yasuda M, Furihata M.
 Pseudosarcomatous proliferation of cx43- and kit-expressing interstitial cell
 in the urinary bladder. Patholog Res Int.
Takeuchi T, Iwasaki S, Miyazaki J, Nozaki Y, Takahashi M, Ono M,
Saibara T,Furihata M.

 Matrix metalloproteinase-1 expression in splenic angiosarcoma metastasizing
 to the serous membrane. Int J Clin Exp Pathol. 3(6) :634-9
Adachi Y, Takeuchi T, Nagayama T, Furihata M.
 T-cadherin modulates tumor-associated molecules in gallbladder cancer cells.
 Cancer Invest. (2010)
Yamasaki K, Hayashi Y, Okamoto S, Osanai M, Lee GH.  
 Insulin-independent promotion of chemically induced hepatocellular tumor development  in genetically diabetic mice. Cancer Sci. (2010)
Ikezoe T, Takeuchi T, Yang J, Adachi Y, Nishioka C, Furihata M, Koeffler HP, Yokoyama A 
 Analysis of Aurora B kinase in non-Hodgkin lymphoma. Laboratory Investigation. 89(12)  :1364-1373
Kurabayashi A
, Iguchi M, Matsumoto M, Hiroi M, Kume M, Furihata M.

 Thymic mucosa-associated lymphoid tissue lymphoma with immunoglobulin-storing
 histiocytosis in Sjogren's syndrome. Pathol Int. (2010)

2009年
Takahashi M, Miyazaki H, Furihata M, Sakai H, Konakahara T, Watanabe M, Okada T
 Chemokine CCL2/MCP-1 negatively regulates metastasis in a highly bone marrow-
 metastatic mouse breast cancer model. Clin Exp Metastasis.26(7):817-828
Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M
 Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder 
 cancer.FEBS Lett. 22;583(2):430-436
Chung S,Furihata M, Tamura K, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
 Overexpressing PKIB in prostate cancer promotes its aggressiveness by linking 
 between PKA and Akt pathways.Oncogene 28(32):2849-2859
Tamura K, Furihata M, Chung SY, Uemura M, Yoshioka H, Iiyama T, Ashida S, Nasu Y, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
 Stanniocalcin 2 overexpression in castration – resistant prostate cancer and 
 aggressive prostate cancer. Cancer Sci. 100(5):914-919
Chung S, Tamura K, Furihata M, Uemura M, Daigo Y, Nasu Y, Miki T, Shuin T, Fujioka T, Nakamura Y, Nakagawa H
 Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1)
 in castration-resistant prostate cancer.Cancer Sci. 100(11):2109-2114
Tamura K, Makino A, Hullin-Matsuda F, Kobayashi T, Furihata M, Chung S, Ashida S, Miki T, Fujioka T, Shuin T, Nakamura Y, Nakagawa H
 
Novel lipogenic enzyme ELOVL7 is involved in prostate cancer growth through
 saturated long-chain fatty acid metabolism. Cancer Res. 69(20):8133-8140


2008年
Adachi Y, Takeuchi T, Nagayama T, Ohtsuki Y, Furihata M.
 Zeb1-mediated T-cadherin repression increases the invasive potential of
 gallbladder cancer.FEBS Lett. (2008)
Iguchi M, Kakinuma Y, Kurabayashi A, Sato T, Shuin T, Hong SB,
 Schmidt LS, Furihata M.

 Acute inactivation of the VHL gene contributes to protective effects of
 ischemic preconditioning in the mouse kidney. Nephron Exp Nephrol.110(3):82-90
Hayashi Y, Toda K, Saibara T, Okamoto S, Osanai M, Enzan H, Lee GH.
 Expression of fascin-1, an actin-bundling protein, in migrating hepatoblasts
 during rat liver development. Cell Tissue Res.334(2):219-26



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