高知大学医学部眼科学教室 研究業績 発表論文  
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2006年
 
1. Fukushima A, Sumi T, Fukuda K, Yamaguchi T, Kumagai N, Nishida T, Ueno H.
Modulation of murine experimental allergic conjunctivitis by treatment with α-galactosylceramide.
Immunol Lett. 107(1): 32-40, 2006.
2. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Tsuru E, Ueno H.
Analysis of the interaction between IFN-γ and IFN-γR in the effector phase of experimental murine allergic conjunctivitis.
Immunol Lett. 107(2): 119-124, 2006
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3. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Taniguchi T, Liu F-T, Ueno H.
Genetic background determines susceptibility to experimental immune-mediated blepharoconjunctivitis:Comparison of Balb/c and C57BL/6 mice.
Exp Eye Res. 82(2): 210-218, 2006.
4. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Yagita H, Ueno H.
Roles of OX40 in the development of murine experimental allergic conjunctivitis:exacerbation and attenuation by stimulation and blocking of OX40.
Invest Ophthalmol Vis Sci. 47(2): 657-663, 2006.
5. Fujishima H, Fukagawa K, Takano Y, Okamoto S, Nakagawa Y, Uchio E, Yokoi N, Fukushima A, Takamura E.
The early efficacy of topical levocabastine in patients with allergic conjunctivitis.
Allergol Int. 55(3): 301-303, 2006.
6. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Ueno H.
TLR2 agonist ameliorates murine experimental allergic conjunctivitis by inducing CD4 positive T-cell apoptosis rather than by affecting the Th1/Th2 balance.
Biochem Biophys Res Commun. 339(4): 1048-1055, 2006.
7. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Ueno H.
Role of VLA-4 in the development of allergic conjunctivitis in mice.
Mol Vis. 12(4): 310-317, 2006.
8. Fukushima A, Yamaguchi T, Ishida W, Fukata K, Liu F T, Ueno H.
Cyclosporin A inhibits eosinophilic infiltration into the conjunctiva mediated by type IV allergic reactions.
Clin Exp Ophthalmol. 34(4): 347-353, 2006.
9. Koura Y, Fukushima A, Nishino K, Ishida W, Nakakuki T, Sento M, Yamazoe K, Yamaguchi T, Miyoshi T, Ueno H.
Inflammatory reaction following cataract surgery and implantation of acrylic intraocular lens in rabbits with endotoxin-induced uveitis.
Eye 20(5): 606-610, 2006.
10. Daibata M, Nemoto Y, Togitani K, Fukushima A, Ueno H, Ouchi K, Fukushi H, Imai S, Taguchi H.
Absence of Chlamydia psittaci in ocular adnexa1 1ymphoma from Japanese patients.
Br J Haematol. 132(5): 651-652, 2006.
11. Fukushima A, Yamaguchi T, Azuma M, Yagita H, Ueno H.
Involvement of programmed death-ligand 2 (PD-L2) in the development of experimental allergic conjunctivitis in mice.
Br. J. Ophthalmol. 90(8): 1040-1045, 2006.
12. Fukushima A, Yamaguchi T, Fukuda K, Sumi T, Kumagai N, Nishida T, Imai S, Ueno H.
CD8+ T cells play disparate roles in the induction and the effector phases of murine experimental allergic conjunctivitis.
Microbiol Immunol. 50(9): 719-728, 2006.
13. Fukushima A, Hatanaka Y, Chang J W, Takamatsu M, Singh N, Iwashima M.
Lck couples Shc to TCR signaling.
Cell Signal. 18(8): 1182-1189, 2006.
14. Okumura N, Fukushima A, Igarashi A, Sumi T, Yamagishi T, Ueno H.
Pharmacokinetic analysis of platelet-activating factor in the tears of guinea pigs with allergic conjunctivitis.
J Ocul Pharmacol Ther. 22, 347-352, 2006
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15. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H.
IL-10 and TGF-β contribute to the development of experimentally-induced allergic conjunctivitis in mice during the effector phase.
Br J Ophthalmol. 90(12): 1535-1541, 2006.
16. Kubo M, Ozaki A, Tanaka S, Okamoto M, Fukushima A.
Role of suppressor of cytokine signaling in ocular allerg.
Curr Opin Allergy Clin Immunol 6: 361-366, 2006.
17. Zinchuk O, Watanabe M, Hayashi N, Fukushima A, Ueno H.
A case of tamoxifen keratopathy.
Arch Ophthalmol 124:1046-1048, 2006.
 
2007年
 
1. Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Yagita H, Ueno H.
Differential contributions of B7-1 and B7-2 to the development or murine experimental allergic conjunctivitis.
Immunol Lett.108(1): 62-67, 2007.
2. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Akiba H, Okumura K, Yagita H, Ueno H.
Antibodies to T-cell Ig and mucin domain-containing proteins(Tim)-1 and-3 suppress the induction and progression of murie allergic conjunctivitis.
Biochem Biophys Res Commun.353(1): 211-216, 2007.
3. Sumi T, Fukushima A, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
Thymus-derived CD4 + CD25 + T cells suppress the development of murine allergic conjunctivitis.
Int Arch Allergy Immunol. 143(4): 276-281, 2007.
4. Fukushima A, Yamaguchi T, Sumi T, Fukuda K, Kumagai N, Nishida T, Takeuchi M, Taguchi O, Ueno H.
Roles of CD4+CD25+T cells in the development of experimental murine allergic conjunctivitis.
Graefe’s Arch Clin Exp Ophthalmol. 245(5): 705-714, 2007.
5. Fukushima A, Sumi T, Fukuda K, kumagai N, Nishida T, Ueno H.
Endogenous IL-10 produced by antigen-irrelevant cells promotes the development of experimental murine allergic conjunctivitis.
Int Arch Allergy Immunol. 144(1): 79-84, 2007.
6. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, Akiba H, Yagita H, Ueno H.
T-cell Ig and mucin domain-containing protein(Tim)-2 regulates murine allergic conjunctivitis during the effector phase.
Immunol Lett. 110(2): 133-138, 2007.
7. Fukushima A, Shii D, Sumi T, Kageyama T, Ueno H.
Cryptomeria japonica-induced allergic conjunctivitis in mice.
Biol Pharm Bull. 30(9): 1745-1747, 2007.
8. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Yamazaki T, Akiba H, Okumura K, Yagita H, Ueno H.
B7-H3 regulates the development of experimental allergic conjunctivitis in mice.
Immunol Letters. 113(1): 52-57, 2007.
9. Shii D, Fukushima A.
Current Pharmaceutical Analysis 3:213-220, 2007
10. Fukushima A.
Cornea 26(Suppl 1):S36-S40, 2007
11. Yamamoto Y, Fukushima A, Nishino K, Koura Y, Komatsu T, Ueno H.
Jpn J Ophthalmol 51:60-63, 2007
 
2008年
 
1. Fukushima A, Sumi T, Fukuda K, Kumagai N, Nishida T, Okumura K, Akiba H, Yagita H, Ueno H.
Roles of galectin-9 in the development of experimental allergic conjunctivitis in mice.
Int Arch Allergy Immunol 146:36-43, 2008.
2. Yamamoto Y, Komatsu T, Koura Y, Nishino K, Fukushima A, Ueno H.
Intraocular pressure elevation after intravitreal or posterior sub-Tenon triamcinolone acetonide injection.
Can J Ophthalmol 43:42-47, 2008.
3. Fukushima A, Sumi T, Ishida W, Ojima A, Kajisako M, Ueno H, Taguchi O.
Depletion of thymus-derived CD4+CD25+ T cells abrogates the suppressive effects of α-galactosylceramide treatment on experimental allergic conjunctivitis.
Allergol Int, 57: 241-246, 2008.
4. Fukushima A, Sumi T, Ishida W, Yamada J, Iwakura Y, Ueno H.
Endogenous IL-17 does not play a significant role in the development of experimental murine allergic conjunctivitis.
Int Arch Allergy Immunol 147: 206-212, 2008.
5. Fujishima H, Fukagawa K, Tanaka M, Uchio E, Takamura E, Nakagawa Y, Miyazaki D, Fukushima A, Okamoto S, Yokoi N.
The Effect of a Combined Therapy with a Histamine H(1) Antagonist and a Chemical Mediator Release Inhibitor on Allergic Conjunctivitis.
Ophthalmologica. 222: 232-239, 2008.
6. Sumi T, Ishida W, Ojima A, Kajisako M, Sakanishi T, Yagita H, Fukushima A.
CD27 and CD70 do not play a critical role in the development of experimental allergic conjunctivitis in mice.
Immunol Lett, 119: 91-96, 2008.
7. Fukushima A, Sumi T, Ishida W, Ojima A, Kajisako M, Koyanagi A, Koyama N, Yagita H.
Notch ligand Delta-like4 inhibits the development of murine experimental allergic conjunctivitis.
Immunol Lett, 121: 140-147, 2008. ( Fukushima's 100th Anniversary!! )
   
 
 
 
 
1. Sumi T, Ishida W, Mittler RS, Yagita H, Taguchi O, Fukushima A.
Regulatory T cells participate in 4-1BB-mediated suppression of experimental allergic conjunctivitis.
Int. Arch. Allergy Immunol., 148(4):305-310,2009.
2. Sumi T, Ishida W, Okumura K, Yagita H, Fukushima A.
Activation of tumor necrosis factor-related apoptosis-inducing ligand receptor enhances the severity of murine allergic conjunctivitis.
Br. J. Ophthalmol., 93(1):110-115, 2009
3. Sumi T, Fukushima A, Nishino K, Fukuda K, Kumagai N, Nishida T, Ueno H.
Treatment with FTY720 during the induction or effector phase suppresses the development of experimental allergic conjunctivitis in mice.
Cell. Biol. Int., 33(4):534-541, 2009
4. Miyazaki D, Nakamura T, Ohbayashi M, Kuo CH, Komatsu N, Yakura K, Tominaga T, Inoue Y, Higashi H, Murata M, Takeda S, Fukushima A, Liu FT, Rothenberg ME, Ono SJ.
Ablation of type I hypersensitivity in experimental allergic conjunctivitis by eotaxin-1/CCR3 blockade.
International Immunology, 21(2):187-201, 2009
5. Yamada J, Hamuro J, Fukushima A, Ohteki T, Terai K, Iwakura Y, Yagita H,
Kinoshita S. MHC-matched corneal allograft rejection in an IFN-gamma/IL-17-independent manner in C57BL/6 mice.
Invest. Ophthalmol. Vis. Sci., 50(5):2139-2146, 2009.
6. Fukushima A, Tomita T.
Image analyses of the kinetic changes of conjunctival hyperemia in histamine-induced conjunctivitis in guinea pigs.
Cornea, 28(6): 694-698, 2009.
7. Fujishima H, Fukagawa K, Takano Y, Tanaka M, Okamoto S, Miyazaki D, Yamada J, Fukushima A, Uchio E.
Comparison of Efficacy of Bromfenac Sodium 0.1% Ophthalmic Solution and Fluorometholone 0.02% Ophthalmic Suspension for the Treatment of Allergic Conjunctivitis.
J. Ocul. Pharmacol. Ther., 25(3):265-270, 2009.
8. Ebihara N, Ohashi Y, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Nanba K, Fukushima A, Fujishima H.
A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in thetreatment of severe allergic conjunctivitis.
J. Ocul. Pharmacol. Ther., 25(4):365-371, 2009.
9. Sakamoto S, Aoki K, Higuchi T, Todaka H, Morisawa K, Tamaki N, Hatano E, Fukushima A, Taniguchi T, Agata Y.
The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.
Mol. Cell. Biol., 29(13):3754-3769, 2009.
10. Fukushima A, Tomita T.
Image analyses of conjunctival hyperemia in guinea pig allergic conjunctivitis.
Graefe's Arch. Clin. Exp. Ophthalmol., 247(11):1571-1572, 2009.
11. Ishida W, Tsuru E, Tominaga A, Miyazaki, Higuchi T, Sakamoto S, and Fukushima A.
Systemic overexpression of IFN-γ and IL-5 exacerbates early phase reaction and conjunctival eosinophilia, respectively, in experimental allergic conjunctivitis.
Br. J. Ophthalmol., 93(12):1680-1685, 2009.
12. Yamamoto Y, Nakakuki T, Nishino K, Yagyu K, Ueno H, Fukushima A.
Histological and clinical study of eyes with true exfoliation and a double-ring sign on the anterior lens capsule.
Can. J. Ophthalmol., 44(6):657-662, 2009.
 
 
1. Fukushima A, Ishida W, Ojima A, Kajisako M, Sumi T, Yamada J, Tsuru E, Miyazaki J-i, Tominaga A, Yagita H.
Participation of CD11b and F4/80 molecules in the conjunctival eosinophilia of experimental allergic conjunctivitis.
Int Arch Allergy Immunol, 151(2):129-136, 2010.
2. Ohashi Y, Ebihara N, Fujishima H, Fukushima A, Kumagai N, Nakagawa Y, Nanba K, Okamoto S, Shoji J, Takamura E, Hayashi K.
A randomised, placebo-controlled clinical trial of tacrolimus ophthalmic suspension 0.1% in severe allergic conjunctivitis.
J Ocul Pharmacol Ther, 26(2):165-174, 2010.
3. Sumi T, Ishida W. Ebihara N, Fukushima A.
T cell-related co-stimulatory molecules in the conjunctiva of patients with severe allergic conjunctivitis.
Cornea, 29: 622-627, 2010.
4. Miyazaki D, Ishida W, Tominaga T, Sumi T, Fukushima A.
Aggravation of conjunctival early-phase reaction by staphylococcus aureus enterotoxin B via augmentation of IgE production.
Jpn J Ophthalmol, 54(5): 476-480, 2010.
5. Takahashi A, Sumi T, Tada K, Mibu, Shii D, Kayasuga A, Fukushima A.
Evaluation of histamine-induced conjunctival edema in guinea-pigs using image analysis.
Br J Ophthalmol, 94(12): 1657-1661, 2010.
6. Ishida W, Kajisako M, Takahashi A, Sumi T, van Rooijen N, Fukuda K, Fukushima A.
Conjunctival macrophages act as antigen-presenting cells in the conjunctiva during the development of experimental allergic conjunctivitis.
Mol Vision, 16: 1280-1285, 2010.
7. Fukuda K, Yamada N, Nishida T.
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation.
Allergol Int, 59(3): 309-312, 2010
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8. Fukuda K, Nishida T.
Ocular allergic inflammation: interaction between the cornea and conjunctiva.
Cornea. 29(11): 62-67, 2010.
 
 
1. Ishida W, Fukuda K, Higuchi T, Kajisako M, Sakamoto S, Fukushima A.
Dynamic changes of microRNAs in the eye during the development of experimental autoimmune uveoretinitis.
Invest Ophthalmol Vis Sci, 52(11): 611-617, 2011.
2. Ishida W, Fukuda K, Sumi T, Ebihara N, Kajisako M, Matsuda H, Yagita H,
Fukushima A.
Adjuvants determine the contribution of basophils to antigen sensitization in vivo.
Immunol Lett, 136: 49-54, 2011.
3. Fukuda K, Nishida T, Fukushima A.
Synergistic induction of eotaxin and VCAM-1 expression in human corneal fibroblasts by staphylococcal peptidoglycan and either IL-4 or IL-13.
Allergol Int, 60: 191-203, 2011.
4. Ishida W, Fukuda K, Sakamoto S, Koyama N, Koyanagi A, Yagita H, Fukushima A.
Regulation of experimental autoimmune uveoretinitis by anti-Delta-like ligand 4 monoclonal antibody.
Invest Ophthalmol Vis sci, 52(11): 8224-8230, 2011.
 
5. Ishida W, Fukuda K, Kajisako M, Sumi T, Matsuda H, Yagita H, Fukushima A.
B and T lymphocyte attenuator regulates the development of antigen induced experimental conjunctivitis.
Graefe's Arch Clin Exp Ophthalmol, in press.
 
6. Fukuda K, Chikama T, Takahashi M, Nishida T.
Long-term follow-up after lamellar keratoplasty in a patient with bilateral idiopathic corneal keloid.
Cornea, in press
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